虎の門病院肝胆膵外科の臨床研究 | 虎の門病院肝胆膵外科

新着情報

肝細胞癌術後の再発形式（ステージ・時間）は相補的に予後を予測する

肝癌術後の早期再発は予後不良因子と考えられ、切除やラジオ波などの根治的治療を控える施設が多くあります。しかし、肝癌再発後の予後は再発形式と時間に相補的に影響され、早期再発でもBCLC stage 0-Aの症例では根治的治療を選択するかどうかで予後が大きく異なることが示されました。
Shindoh J, et al. Ann Surg Oncol 2023; 30(6):3402-10.

T2胆嚢癌の予後の違いは漿膜下層の脈管密度に影響される可能性がある

T2胆嚢癌は肝側と腹腔側で予後が異なる可能性が報告されていますが（Shindoh J, Ann Surg 2015）そのメカニズムは不明でした。
病理組織学的検討から、肝側と遊離腹腔側の脈管密度の違いが、T2胆嚢癌の進展、予後に影響を与えている可能性が示唆されました。
Akabane M, et al. Langenbecks Arch Surg 2023;408(1):73.

レンバチニブ投与を行った進行肝癌に対する手術介入は予後を改善する

肝細胞癌領域においては新規薬剤の登場により切除を含めた根治的治療へのコンバージョンの可能性に期待が寄せられています。当院の前向きデータの解析より、経過中のいわゆるコンバージョン手術を含めた治療介入が進行肝癌における予後改善をもたらすことが示されました。
Shindoh J, et al. J Gastrointest Surg 2022;26(8):1637-46.

冲中記念成人病研究所肝胆膵外科疾患研究チーム

当科スタッフは虎の門病院に併設する冲中記念成人病研究所の研究員を兼任しています。High volume centerに籍をおく医師の責務は、クオリティの高い医療の提供はもちろんのこと、学術活動を通じて新しいエビデンスを世界に発信し、医学の進歩へ貢献を行うことにもあります。2014年以降、当科の研究チームは以下の通り多数の研究成果を発表しており、特に肝臓外科分野では世界へ向けて多くの重要な知見を報告しています。

発表論文

2024年
Shindoh J, Kawamura Y, Akahoshi K, Matsumura M, Okubo S, Akuta N, Tanabe M, Kokudo N, Suzuki Y, Hashimoto M. Clinical utility of the novel oncological criteria of resectability for advanced hepatocellular carcinoma. Liver Cancer 2024.

Akahoshi K, Shindoh J, Tanabe M, Watanabe S, Takamizawa H, Eguchi S, Endo I, Kubo S, Taketomi A, Nagano H, Nakamura M, Hasegawa K, Hatano E, Yoshizumi T, Kokudo N. Questionnaire survey of Japanese board-certified expert hepatobiliary and pancreatic surgeons and instructors on the surgical indications for hepatocellular carcinoma. J Hepatobiliary Pancreat Sci 2024;31(3):143-151.

Kawamura Y, Akuta N, Shindoh J, Matsumura M, Okubo S, Tominaga L, Yamamoto S, Eriksson Y, Hosaka T, Saitoh S, Sezaki H, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kozuka T, Kumada H. Newly established borderline resectable 1 (BR1) category is one of the favorable candidates for selecting the use of multidisciplinary combination therapy in patients with advanced hepatocellular carcinoma treated with systemic therapy. Hepatol Res 2024 Sep 26.

Murakami H, Okubo S, Kami S, Kobayashi M, Matsumura M, Shindoh J, Hashimoto M. Resection of a retroperitoneal lumbar vein aneurysm: A case report. Asian J Endosc Surg 2024;17(3):e13311.

2023年
Shindoh J, Matsumura M, Kobayashi M, Akabane M, Okubo S, Hashimoto M. Disease-free interval and tumor stage complementarily predict the biological behavior of recurrent hepatocellular carcinoma. Ann surg Oncol 2023;30(6):3402-10.

Akabane M, Shindoh J, Kohno K, Kojima K, Okubo S, Matsumura M, Takazawa Y, Hashimoto M. Subserosal vascular density predicts oncological features of T2 gallbladder cancer. Langenbecks Arch Surg 2023;408(1):73.

Ichida A, Arita J, Hatano E, Eguchi S, Saiura A, Nagano H, Shindoh J, Hashimoto M, Takemura N, Taura K, Sakamoto Y, Takahashi Y, Seyama Y, Sasaki Y, Uemura K, Kokudo N, Hasegawa K. Ichida A, Arita J, Hatano E, Eguchi S, Saiura A, Nagano H, Shindoh J, Hashimoto M, Takemura N, Taura K, Sakamoto Y, Takahashi Y, Seyama Y, Sasaki Y, Uemura K, Kokudo N, Hasegawa K. Liver Cancer2023; 28:13(3):322-34.

Matsumura M, Kobayashi M, Okubo S, Haruta S, Koyama R, Uruga H, Shindoh J, Imamura T, Takazawa Y, Hashimoto M. Total pancreatectomy with remnant stomach preservation in a patient with a history of proximal gastrectomy and interposed jejunal reconstruction with right gastroepiploic conduit preservation: a case report. Surg Case Rep 2023;9(1):117.

Kawamura Y, Akuta N, Shindoh J, Matsumura M, Okubo S, Tominaga L, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kozuka T, Kumada H. Efficacy of the Combination of Systemic Sequential Therapy and Locoregional Therapy in the Long-Term Survival of Patients with BCLC Stage C Hepatocellular Carcinoma. Cancers 2023;15(15):3789.

Muraishi N, Kawamura Y, Akuta N, Shindoh J, Matsumura M, Okubo S, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Yasuda I, Kumada H. The Impact of Lenvatinib on Tumor Blood Vessel Shrinkage of Hepatocellular Carcinoma during Treatment: An Imaging-Based Analysis. Oncology 2023;101(2):134-144.

Kobayashi Y, Shindoh J, Kojima K, Akabane M, Kobayashi M, Okubo S, Matsumura M, Hashimoto M. Efficacy and safety of postoperative preemptive use of tolvaptan for patients with cirrhosis undergoing hepatectomy for hepatocellular carcinoma. Langenbecks Arch Surg 2023; 408(1):381.

Kojima K, Shindoh J, Matsumura M, Okubo S, Hashimoto M. A preoperative risk score based on multifrequency bioelectrical impedance analysis in patients undergoing liver resection. Langenbecks Arch Surg 2023;408(1):44.

Akabane M, Shindoh J, Kobayashi Y, Okubo S, Matsumura M, Hashimoto M. Risk stratification of patinets with marginal hepatic functional reserve using the remnant hepatocyte uptake index in gadoxetic acid-enhanced magnetic resonance imaging for safe liver surgery. World J Surg 2023; 47(4):1042-8.

Kawamura Y, Akuta N, Shindoh J, Matsumura M, Okubo S, Tominaga L, Fujimaya S, Hosaka T, Saitoh S, Sezaki H, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kozuka T, Kumada H. Well-preserved liver function enhances the clinical impact of curative-intent subsequent treatment during lenvatinib treatment for unresectable hepatocellular carcinoma. Clin J Gastroenterol 2023;16(1):1-12.

2022年
Shindoh J, Kawamura Y, Kobayashi M, Akuta N, Okubo S, Matsumura M, Suzuki Y, Hashimoto M. Prognostic advantages of individual additional interventions after lenvatinib therapy in patients with advanced hepatocellular carcinoma. J Gastrointest Surg 2022; 26(8):1637-1646.

Okubo S, Shindoh J, Kobayashi Y, Matsumura M, Hashimoto M. Adhesions as a risk factor for postoperative morbidity in patients undergoing repeat hepatectomy and the potential efficacy of adhesion barriers. J Hepatobiliary Pancreat Sci 2022; 29(6): 618-628.

Okubo S, Kojima K, Makuuchi M, Kobayashi Y, Shindoh J, Hashimoto M. Clinical impact of the new “twin U-stitch method” of pancreaticogastrostomy in pancreaticoduodenectomy. Langenbecks Arch Surg 2022; 407(3):1263-1269.

Akabane M, Kobayashi Y, Kinowaki K, Okubo S, Shindoh J, Hashimoto M. Primary hepatic neuroendocrine noplasm diagnosed by somatostatin receptor scintigraphy: a case report. World J Clin Cases 2022; 10(7):2222-2228.

Kawaguchi S, Okubo S, Haruta S, Shindoh J, Hashimoto M, Ueno M. Indocyanine green fluorescence angiography-guided simultaneous laparoscopic distal gastrectomy and spleen-preserving distal pancreatectomy for conserving the gastrosplenic ligament: A case report. Int J Surg Case Rep 2022, 92:106803.

Kawamura Y, Kobayashi M, Shindoh J, Matsumura M, Okubo S, Muraishi N, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Akuta N, uzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kumada H. Pretreatment positron emission tomography with 18F-fluorodeoxyglucose may be a useful new predictor of early progressive disease following atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma. Oncology 2022; 100(6):320-330.

Muraishi N, Kawamura K, Kobayashi M, Shindoh J, Kobayashi Y, Okubo S, Iritani S, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Akuta N, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Yasuda I, Kumada H. Changes in mean intrahepatic target CT attenuation value during treatment may be a useful new predictor of post-progression survival associated with lenvatinib treatment. Int Med 2022; 61(7):951-958.

Shindoh J. Multidisciplinary approach to the treatment of advanced hepatocellular carcinoma in the era of new biologic agents. J Nippon Med Sch 2022;89(2):145-153.

Asai K, Iwashita Y, Ohyama T, Endo I, Hibi T, Umezawa A, Suzuki K, Watanabe M, Kurata M, Mori Y, Higashida M, Kumamoto Y, Shindoh J, Yoshida M, Honda G, Misawa T, Abe Y, Nagakawa Y, Toyota N, Yamada S, Norimizu S, Matsumura N, Sata N, Sunagawa H, Ito M, Takeda Y, Nakamura Y, Rikiyama T, Higuchi R, Gocho T, Honma Y, Hirashita T, Kanemoto H, Nozawa M, Watanabe Y, Kohga A, Yazawa T, Tajima H, Nakahira S, Asaoka T, Yoshioka R, Fukuzawa J, Fujioka S, Hata D, Haruta H, Asano Y, Nomura R, Matsumoto J, Kameyama N, Miyoshi A, Urakami H, Seyama Y, Morikawa T, Kawano Y, Ikoma H, Kin T, Takada T, Yamamoto M. Application of a novel surgical difficulty grading system during laparoscopic cholecystectomy. J Hepatobiliary Pancreat Sci 2022; 29(7):758-767.

Umino R, Kobayashi Y, Akabane M, Kojima K, Okubo S, Hashimoto M, Shindoh J. Preoperative nutritional score predicts underlying liver status and surgical risk of hepatocellular carcinoma. Scand J Surg 2022; 111(1):14574969211061953.

Ohkura Y, Shindoh J, Ichikura K, Udagawa H, Ueno M, Matsushima E. Perioperative risk factors for psychological distress in patients undergoing treatment for esophageal cancer. BMC Psychology 2022; 10(1):214.

Akabane M, Okubo S, Kinowaki K, Matsumura M, Shindoh J, Hashimoto M. Liver metastasis from rectal neuroendocrine neoplasm detected 15 years after primary resection. Surg Case Rep 2022; 8(1):212.

Murakami H, Okubo S, Kobayashi M, Akabane M, Matsumura M, Shindoh J, Hashimoto M. Gallbladder cancer concomitant with autosomal dominant polycystic kidney disease: A case report. Clin Case Rep 2022;10(12):e6734.

Okubo S, Shindoh J, Matsumura M, Hashimoto M. Safety and efficacy of gelatin-thrombin matrix sealants (Floseal®) for hemostasis during liver resection. Surg Gastroenterol Oncol, epub Dec 2022

Okubo S, Shindoh J, Kobayashi Y, Hashimoto M. Simple prediction model for platelet increase after non-trauma splenectomy. Ind J Surg, epub Dec 2022.

2021年
Shindoh J, Kobayashi Y, Umino R, Kojima K, Okubo S, Hashimoto M. Successful anatomic resection of tumor-bearing portal territory delays long-term stage progression of hepatocellular carcinoma. Ann Surg Oncol 2021, 28(2): 844-853.

Shindoh J. Multidisciplinary approach to the treatment of advanced hepatocellular carcinoma in the era of new biologic agents. J Nippon Med Sch 2021; 89(2):145-153.

Umino R, Shindoh J, Kobayashi Y, Akabane M, Kojima K, Okubo S, Hashimoto M. Comparison of nutritional /inflammatory scores as a preoperative predictor of short-term surgical risks in patients undergoing hepatectomy for colorectal liver metastases. Surg Gastroenterol Oncol 2021;26(2): 97-103.

Kasuya K, Kawamura Y, Kobayashi M, Shindoh J, Kobayashi Y, Kajiwara A, Iritani S, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Akuta N, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Eguchi Y, Hashimoto M, Kumada H. Efficacy and safety of ramucirumab in patients with unresectable hepatocellular carcinoma with progression after treatment with lenvatinib. Intern Med 2021; 60(3):345-351.

Kurata M, Iwashita Y, Ohyama T, Endo I, Hibi T, Umezawa A, Suzuki K, Watanabe M, Asai K, Mori Y, Higashida M, Kumamoto Y, Shindoh J, Yoshida M, Honda G, Misawa T, Abe Y, Nagakawa Y, Toyota N, Yamada S, Norimizu S, Matsumura N, Sata N, Sunagawa H, Ito M, Takeda Y, Nakamura Y, Rikiyama T, Higuchi R, Gocho T, Ueno K, Kumagai Y, Kanaji S, Takada T, Yamamoto M. Assembling a library of typical surgery video clips to construct a system for assessing the surgical difficulty of laparoscopic cholecystectomy. J Hepatobiliary Pancreat Sci 2021; 28(3):255-262.

Okubo S, Shindoh J, Kobayashi Y, Umino R, Akabane M, Kojima K, Hashimoto M. Adipose tissue distribution predicts prognosis of cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma. Ann Surg Oncol 2021; 28(11):6738-6746.

Kojima K, Shindoh J, Akabane M, Umino R, Kobayashi Y, Okubo S, Hashimoto M. Usefulness of serum anti-p53 antibody measurement in patients undergoing hepatectomy for colorectal liver metastases. World J Surg 2021; 45(6): 1906-1912.

Shindoh J. Risk stratification and goal of systemic therapy for successful surgical management of colorectal liver metastases: oncological optimization. J Hepatobiliary Pancreat Sci 2021; 28(6):461-469.

Shindoh J, Kawamura Y, Kobayashi Y, Kobayashi M, Akuta N, Okubo S, Suzuki Y, Hashimoto M. Prognostic impact of surgical intervention after lenvatinib treatment for advanced hepatocellular carcinoma. Ann Surg Oncol 2021; 38(12):7663-7672.

Hiramatsu K, Shindoh J, Hanaoka Y, Toda S, Ueno M, Matoba S, Kuroyanagi H. Postoperative nutritional status is predictive of the survival outcomes in patients undergoing resection of stage III colorectal cancer. World J Surg 2021; 45(10)3198-3205.

Akabane M, Shindoh J, Kobayashi Y, Umino R, Kojima K, Okubo S, Hashimoto M, Matoba S, Kuroyanagi H. Significance of preoperative nutritional status as a predictor for short-term and long-term outcomes of patients undergoing surgery for stage IV colorectal cancer. Langenbecks Arch Surg 2021; 406(7):2391-2398..

Kawamura Y, Kobayashi M, Shindoh J, Kobayashi Y, Okubo S, Muraishi N, Iritani S, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Akuta N, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kumada H. Pretreatment positron emission tomography with 18F-fluorodeoxyglucose may be a useful new predictor of overall prognosis following lenvatinib treatment. Oncology 2021; 99(10):611-621.

Ochiai Y, Kawamura Y, Kobayashi M, Shindoh J, Kobayashi Y, Okubo S, Muraishi N, Kajiwara A, Iritani S, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, akuta N, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kumada H. Effects of alcohol consumption on multiple hepatocarcinogenesis in patients with fatty liver disease. Hepatol Res 2021; 51(1): 62-68.

Kobayashi Y, Shindoh J, Okubo S, Tani K, Morito M, Kojima K, Umino R, Igata Y, Hashimoto M. Hyaluronic acid/carboxymethyl cellulose-based adhesion barrier reduces surgical difficulty and complication in repeat hepatectomy. HPB 2021; 23(6):907-914.

Okubo S, Shindoh J, Kobayashi Y, Hashimoto M. Safety of bioabsorbable membrane (Seprafilim®) in hepatectomy in the era of aggressive liver surgery. HPB 2021, 23(4):528-532.

Yamashige D, Kawamura Y, Kobayashi M, Shindoh J, Kobayashi Y, Okubo S, Muraishi N, Kajiwara A, Iritani S, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Akuta N, Suzuki F Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kumada H. Potential and Clinical Significance of 18F-fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography for Evaluating Liver Cancer Response to Lenvatinib Treatment. Oncology 2021, 99(3):169-176.

2020年
Shindoh J, Kawamura Y, Kobayashi Y, Akuta N, Kobayashi M, Suzuki Y, Ikeda K, Hashimoto M. Time to interventional failure as a new surrogate measure for survival outcomes after resection of hepatocellular carcinoma. J Gastrointest Surg 2020, 24(1):50-57.

Umino R, Kobayashi Y, Urabe M, Okubo S, Shindoh J, Hashimoto M. Extended right surgical margin in distal pancreatectomy with celiac axis resection for pancreatic body cancer under the presence of replaced right hepatic artery; a case report. Int J Surg Case Rep 2020; 76: 557-560.

Urabe M, Shindoh J, Kobayashi Y, Okubo S, Ueno M, Hashimoto M. Factors impacting survival outcomes after curative resection for primary duodenal adenocarcinoma. Surg Gastroneterol Oncol 2020; 25(3): 132-139.

Okubo S, Shindoh J, Kobayashi Y, Hashimoto M. Safety of use of a sheet-type adhesion barrier (Interceed®) during liver surgery. World J Surg 2020; 44(12):4214-4220.

Kawamura Y, Kobayashi M, Shindoh, Kobayashi Y, Okubo S, Tominaga L, Kajiwara A, Kasuya K, Iritani S, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Akuta N, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kozuka T, Kumada H. Lenvatinib-transarterial chemoembolization sequential therapy as an effective treatment at progression during lenvatinib therapy for advanced hepatocellular carcinoma. Liver Cancer 2020, 9(6):756-770.

Kawamura Y, Kobayashi M, Shindoh J, Kobayashi Y, Kasuya K, Sano T, Fujiyama S, Hosaka T, Saitoh S, Sezaki H, Akuta N, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kumada H. Pretreatment heterogeneous enhancement pattern of hepatocellular carcinoma may be a useful new predictor of early response to lenvetinib and overall prognosis. Liver Cancer 2020, 9(3): 275-292.

Kobayashi Y, Shindoh J, Igata Y, Okubo S, Hashimoto M. A novel scoring system for evaluating the difficulty of lysis of adhesion and surgical risk at repeat hepatectomy. J Hepatobiliary Pancreat Sci 2020, 27(4):191-199.

Ohkura Y, Shindoh J, Ueno M, Iizuka T, Udagawa H. Clinicopathologic characteristics of oligometastases from esophageal cancer and long-term outcomes of resection. Ann Surg Oncol 2020, 27(3):651-659.

Ohkura Y, Ichikura K, Shindoh J, Ueno M, Udagawa H, Matsushima E. Relationship between psychological distress and health-related quality of life at each point of the treatment of esophageal cancer. Esophagus 2020, 17(3):312-322.

Kobayashi Y, Shindoh J, Nishioka Y, Inagaki Y, Mitsui J, Arita J, Hasegawa K. Germline MICA polymorphism predicts long-term outcomes of patients undergoing hepatectomy for colorectal liver metastases. J Gastrointest Surg 2020, 24(9):2137-2139.

Kamei K, Ohnishi T, Nakata K, Danno K, Ohkawa A, Miyake Y, Okazaki S, Fukunaga M, Toyokawa A, Hamada T, Shindoh J, Kanazawa A. A new monitoring tool CLIP test for progression of oxaliplatin-induced peripheral neuropathy: a multicenter prospective study. Asia Pac J Clin Oncol 2020, 16(5):e257-262.

Okubo S, Shindoh J, Kobayashi Y, Hashimoto M. Safety of a new spray-type adhesion barrier (AdSpray®) in liver surgery. J Hepatobiliary Pancreat Sci 2020, 27(9): 648-654.

Ohkura Y, Shindoh J, Ichikura K, Udagawa H, Ueno M, Matsushima E. Perioperative risk factors of psychological distress in patients undergoing treatment for esophageal cancer. World J Surg Oncol 2020;18(1):326.

Urabe M, Shindoh J, Kobayashi Y, Okubo S, Haruta S, Ueno M, Hashimoto M. Factors impacting survival outcomes after curative resection for primary duodenal adenocarcinoma. Surg Gastroenterol 2020; 25(3):132.

Igata Y, Kobayashi Y, Okubo S, Shindoh J, Hashimoto M. Resected metachronous renal metastasis of pancreatic cancer after pancreaticoduodenectomy – a case report. Ann Pancreat Cancer 2020, epub Mar 9.

Okuno M, Newhook TE, Joechle K, Kawaguchi Y, De Bellis M, Tzeng CD, Chun YS, Aloia TA, Shindoh J, Kaseb AO, Vauthey JN. Characteristics of atypical large well-differentiated hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma? HPB 2020, 22(4):545-552.

Kawamura Y, Kobayashi M, Shindoh J, Kobayashi Y, Kasuya K, Sano T, Saito S, Sezaki H, Akuta N, Suzuki F, Suzuki Y, Ikeda K, Arase Y, Hashimoto M, Kumada H. 18F-fluorodeoxyglucose uptake in hepatocellular carcinoma as a useful predictor of an extremely rapid response to lenvatinib. Liver Cancer 2020, 9(1):84-92.

Kamei K, Shindoh J, Kiya Y, Matsumoto I, Hashimoto M, Takeyama Y. Conversion surgery after extensive chemotherapy for stage IV mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: clinical implications from the patterns of response and recurrence. Clin J Gastroenterol 2020, 13(2):240-246.

Shindoh J, Kobayashi Y, Kawamura Y, Akuta N, Kobayashi M, Suzuki Y, Ikeda K, Hashimoto M. Microvascular invasion and a size cutoff value of 2 cm predict long-term oncological outcome in multiple hepatocellular carcinoma: reappraisal of the AJCC staging system and validation using the SEER database. Liver Cancer 2020, 9(2):156-166.

Shindoh J. Hypofractionated radiation therapy for unresectable/locally recurrent intrahepatic cholangiocarcinoma. Ann Surg Oncol 2020;27(4):983-984.

Kobayashi Y, Kiya Y, Nishioka Y, Hashimoto M, Shindoh J. Indocyanine green clearance of remnant liver (ICG-Krem) predicts postoperative subclinical hepatic insufficiency after resection of colorectal liver metastasis: theoretical validation for safe expansion of Makuuchi’s criteria. HPB 2020, 22(2): 258-264.

Sugawara T, Hashimoto M, Shindoh J. Laparoscopic left lateral sectionectomy; a three-port method. J Min Access Surg 2020; 16(3):220-223.

2019年
Shindoh J, Kawamura Y, Kobayashi Y, Kiya Y, Suagawara T, Akuta N, Kobayashi M, Suzuki Y, Ikeda K, Hashimoto M. Platelet-albumin score as a sensitive measure for surgical risk prediction and survival outcomes of patients with hepatocellular carcinoma. J Gastrointest Surg 2019, 23(1):76-83.

Ohkura Y, Ueno M, Shindoh J, Iizuka T, Udagawa H. Randomized controlled trial on efficacy of oligomeric formula (HINE E-GEL®)versus polymeric formula (MEIN®) enteral nutrition after esophagectomy for esophageal cancer with gastric tube reconstruction. Dis Esophagus 2019, 32(5).

Ogiso S, Okuno M, Shindoh J, Sakamoto Y, Mizuno T, Araki K, Goumard C, Nomi T, Ishii T, Uemoto S, Chun YS, Tzeng CD, Lee JE, Vauthey JN, Conrad. Conceptual framework of middle hepatic vein anatomy as a road map for safe right hepatectomy. HPB 2019, 21(1):43-50.

Kawamura Y, Ikeda K, Shindoh J, Kobayashi Y, Kasuya K, Fujiyama S, Hosaka T, Kobayashi M, Saitoh S, Sezaki H, Akuta N, Suzuki F, Suzuki Y, Arase Y, Hashimoto M, Kumada H. No-touch ablation in HCC has the potential to prevent intrasubsegmental recurrence to the same degree as surgical resection. Hepatol Res 2019, 49(2):164-176.

Kobayashi Y, Kiya Y, Nishioka Y, Hashimoto M, Shindoh J. Expanded Makuuchi’s criteria using estimated indocyanine green clearance rate of future liver remnant as a safety limit for maximum extent of liver resection. HPB 2019, 21(8):990-997.

Shindoh J. The dawn of a universal language for an emerging malignancy. Chin Clin Oncol 2019, 8(S1):S7.

Kumamoto T, Shindoh J, Mita H, Fujii Y, Mihara Y, Takahashi M, Takemura N, Shirakawa T, Shinohara H, Kuroyanagi H. Optimal diagnostic method using multidetector-row computed tomography for predicting lymph node metastasis in colorectal cancer. World J Surg Oncol 2019, 17(1):39.

Shindoh J, Kawamura Y, Kobayashi Y, Akuta N, Kobayashi M, Suzuki Y, Ikeda K, Hashimoto M. Time to interventional failure as a new surrogate measure for survival outcomes after resection of hepatocellular carcinoma. J Gastrointest Surg 2020, 24(1):50-57.

Shindoh J, Kobayashi Y, Kinowaki K, Mise Y, Gonoi W, Yoshida S, Tani K, Matoba S, Kuroyanagi H, Hashimoto M. Dynamic changes in normal liver parenchymal volume during chemotherapy for colorectal cancer: liver atrophy as an alternate marker of chemotherapy-associated liver injury. Ann Surg Oncol 2019, 26(12):4100-4107.

Shindoh J. Stratification of risk of recurrence after curative-intent treatment for small hepatocellular carcinoma. Hepatobiliary Surg Nutr 2019, 8(6):649-650.

Shindoh J. Japanese experience with hepatic resection of KRAS-mutated colorectal liver metastases. Chin Clin Oncol 2019, 8(5):47

Brudvik W, Shindoh J. Limitations of molecular biomarkers in patients with resectable colorectal liver metastases. Chin Clin Oncol 2019, 8(5):48.

2018年
Mise Y, Hasegawa K, Satou S, Shindoh J, Miki K, Akamatsu N, Arita J, Kaneko J, Sakamoto Y, Kokudo N. How has virtual hepatectomy changed the practice of liver surgery?: Experience of 1194 virtual hepatectomy before live resection and living donor liver transplantation. Ann Surg 2018; 268(1):127-33.

Nishioka Y, Tomizawa K, Hanaoka Y, Toda S, Moriyama J, Matoba S, Kuroyanagi H, Hashimoto M, Shindoh J. Prognostic impact of adjuvant chemotherapy after hepatic resection for colorectal liver metastases. Digestive Surg 2018; 35(3):187-95.

Nishioka Y, Yoshioka R, Gonoi W, Sugawara T, Yoshida S, HashimotoM, Shindoh J. Fluorine-18-fluorodeoxyglucose positron emission tomography as an objective substitute for CT morphologic response criteria in patients undergoing chemotherapy for colorectal liver metastases. Abdominal Imaging 2018; 43(5):1152-8.

Tani K, Shindoh J, Akamatsu N, Arita J, Kaneko J, Sakamoto Y, Hasegawa K, Kokudo N. Management of disappearing lesions after chemotherapy for colorectal liver metastases: relation between detectability and residual tumors. J Surg Oncol 2018; 117(2):191-7.

Omichi K, Shindoh J, Cloyd JM, Mizuno T, Chun YS, Conrad C, Aloia TA, Tzeng CD, Vauthey JN. Liver resection is justified for patients with bilateral multiple colorectal liver metastases: a propensity-score-matched analysis. Eur J Surg Oncol 2018, 44(1):122-129.

Ohkura Y, Shindoh J, Ueno M, Iizuka T, Haruta S, Udagawa H. A new postoperative pain management (intravenous acetaminophen: Acelio®) leads to enhanced recovery after esophagectomy: a propensity score-matched analysis. Surg Today 2018; 48(5):502-9.

Sasaki K, Shindoh J, Nishioka Y, Sugawara T, Margonis GA, Andreatos N, Pawlik TM, Hashimoto M. Postoperative low hepatitis C virus load predicts long-term outcomes after hepatectomy for hepatocellular carcinoma. J Surg Oncol 2018, 117(5):902-11.

Ozaki Y, Shindoh J, Gonoi W, Nishioka Y, Kondoh C, Tanabe Y, Shuichiro M, Kuroyanagi H, Hashimoto M, Takano T. Changes in CT morphology can be an independent response marker for patients receiving regorafenib for colorectal liver metastases: retrospective pilot study. BMC Cancer 2018, 18(1):138.

Fukui Y, Shindoh J, Inoshita N, Mizuno A, Haruta S, Udagawa H, Hoteya S, Tsunoda S, Miyamoto S, Ozawa R, Niwa H, Sakai Y, Shinohara H. Efficacy of endoscopic management for early remnant gastric cancer: is completion gastrectomy truly necessary in cases with marginally non-curative histopathologic features? Ann Surg Oncol 2018, 25(6):1608-15.

Ohkura Y, Shindoh J, Ueno M, Iizuka T, Udagawa H. Comparison of outcome of esophagectomy versus non-surgical treatment for resectable esophageal cancer with clinical complete response to neoadjuvant therapy. Ann Surg Oncol 2018, 25(8): 2428-33.

Nakai Y, Gonoi W, Hagiwara A, Nishioka Y, Abe H, Shindoh J, Hasegawa K. MRI detection of intratumoral fat in colorectal liver metastases after preoperative chemotherapy. Am J Roentgenol 2018, 210(5): W196-W204.

Nishioka Y, Shindoh J, Inagaki Y, Gonoi W, Mitsui J, Abe H, Yoshioka R, Yoshida S, Fukayama M, Tsuji S, Hashimoto M, Hasegawa K, Kokudo N. Host MICA polymorphism as a potential predictive marker for response to chemotherapy for colorectal liver metastases. Dig Dis 2018;36(6):437-445.

Sugawara T, Hashimoto M, Shindoh J. Laparoscopic left lateral sectionectomy; a three-port method. J Min Access Surg 2018, 40(3):331-335.

Ohkura Y, Ueno M, Shindoh J, Iizuka T, Ka H, Udagawa H. Risk factors for postoperative chylothorax after radical subtotal esophagectomy. Ann Surg Oncol 2018;25(9):2739-2746.

Sugawara T Shindoh J, Hoshi D, Hashimoto M. Intrahepatic cholangiocarcinoma and portal hypertension developing in a patient with multicystic biliary microhamartomas. Malays J Pathol 2018; 40(3):331-335.

2017年
Fukui Y, Shindoh J, Matoba S, Tomizawa K, Hanaoka Y, Toda S, Moriyama J, Kuroyanagi H. Successful laparoscopic ligation for massive chylous ascites after rectal cancer surgery. Asian J Endosc Surg 2017; 10(1):55-58.

Hibi T, Iwashita Y, Ohyama T, Honda G, Yoshida M, Takada T, Han HS, Hwang TL, Shinya S, Suzuki K, Umezawa A, Yoon YS, Choi IS, Huang WS, Chen KH, Miura F, Watanabe M, Abe Y, Misawa T, Nagakawa Y, Yoon DS, Jang JY, Yu HC, Ahn KS, Kim SC, Song IS, Kim JH, Yun SS, Choi SH, Jan YY, Sheen-Chen SM, Shan YS, Ker CG, Chan DC, Wu CC, Toyota N, Higuchi R, Nakamura Y, Mizuguchi Y, Takeda Y, Ito M, Norimizu S, Yamada S, Matsumura N, Shindoh J, Sunagawa H, Gocho T, Hasegawa H, Rikiyama T, Sata N, Kano N, Kitano S, Tokumura H, Yamashita Y, Watanabe G, Nakagawa K, Kimura T, Yamakawa T, Wakabayashi G, Endo I, Miyazaki M, Yamamoto M. The “right” way is not always popular; comparison of surgeons’ perceptions during laparoscopic cholecystectomy for acute cholecystitis among experts from Japan, Korea and Taiwan. J Hepatobiliary Pancreat Sci 2017; 24(1):24-32.

Sasaki K, Shindoh J, Nishioka Y, Margonis GA, Sugawara T, Andreatos N, Hashimoto M, Pawlik TM, Impact of viral etiology on postoperative de novo recurrence after hepatectomy for hepatocellular carcinoma in cirrhotic patients. J Gastrointest Surg 2017; 21(3):487-495..

Sasaki K, Shindoh J, Margonis GA, Nishioka Y, Andreatos N, Sekine A, Hashimoto M, Pawlik TM. Effect of background liver cirrhosis on outcomes of hepatectomy for hepatocellular carcinoma. JAMA Surg 2017, 152(3):e165059.

Tani K, Shindoh J, Takamoto T, Shibahara J, Nishioka Y, Hashimoto T, Sakamoto Y, Hasegawa K, Makuuchi M, Kokudo N. Kinetic changes in liver parenchyma after preoperative chemotherapy for patients with colorectal liver metastases. J Gastrointest Surg 2017; 21(5):813-821.

Margonis GA, Sasaki K, Andreatos N, Nishioka Y, Sugawara T, Amini N, Buettner S, Hashimoto M, Shindoh J, Pawlik TM. Prognostic impact of complications after resection of early stage hepatocellular carcinoma. J Surg Oncol 2017, 115(7):791-804.

Iwashita Y, Hibi T, Ohyama T, Honda G, Yoshida M, Miura F, Takada T, Han HS, Hwang TL, Shinya S, Suzuki K, Umezawa A, Yoon YS, Choi IS, Huang WS, Chen KH, Watanabe M, Abe Y, Misawa T, Nagakawa Y, Yoon DS, Jang JY, Yu HC, Ahn KS, Kim SC, Song IS, Kim JH, Yun SS, Choi SH, Jan YY, Shan YS, Ker CG, Chan DC, Wu CC, Lee KT, Toyota N, Higuchi R, Nakamura Y, Mizuguchi Y, Takeda Y, Ito M, Norimizu S, Yamada S, Matsumura N, Shindoh J, Sunagawa H, Gocho T, Hasegawa H, Rikiyama T, Sata N, Kano N, Kitano S, Tokumura H, Yamashita Y, Watanabe G, Nakagawa K, Kimura T, Yamakawa T, Wakabayashi G, Mori R, Endo I, Miyazaki M, Yamamoto M. An opportunity in difficulty: Japan-Korea-Taiwan expert Delphi consensus on surgical difficulty during laparoscopic cholecystectomy. J Hepatobiliary Pancreat Sci 2017;24(4):191-198.

Nishioka Y, Shindoh J, Yoshioka R, Gonoi W, Abe H, Okura N, Yoshida S, Sakamoto Y, Hasegawa K, Fukayama M, Kokudo N. Clinical impact of chemotherapy on microscopic cancer spread surrounding colorectal liver metastases and prediction of surgical curability with the CT morphologic response criteria. Ann Surg Oncol 2017;24(8):2326-2333.

Ohkura Y, Haruta S, Shindoh J, Tanaka T, Ueno M, Udagawa H. Efficacy of prophylactic splenectomy for proximal advanced gastric cancer invading greater curvature. World J Surg Oncol 2017;15(1):106.

Brudvid KW, Jones RP, Giuliante F, Shindoh J, Passot G, Chung MH, Song J, Li L, Dagenborg VJ, Fretland AA, Rosok B, De Rose AM, Ardito F, Edwin B, Panettieri E, Larocca LM, Yamashita S, Conrad C, Aloia TA, Poston GJ, Bjombeth BA, Vauthey JN. RAS mutation clinical risk score to predict survival after resection of colorectal liver metastases. Ann Surg 2017, epub May 25.

Omichi K, Yamashita S, Cloyd JM, Shindoh J, Mizuno T, Chun YS, Conrad C, Aloia TA, Vauthey JN, Tzeng CD. Portal vein embolization reduces postoperative hepatic insufficiency associated with postchemotherapy hepatic atrophy. J Gastrointest Surg 2017, 22(1):60-67.

Sugawara T, Shindoh J, Nishioka Y, Hashimoto M. Total bilirubin amount in drainage fluid can be an early predictor for severe biliary fistula after hepatobiliary surgery. Biosci Trends 2017; 11(5):588-594.

Shindoh J, Nishioka Y, Hashimoto M. Bilateral anatomic resection of the ventral parts of the paramedian sectors of the liver with total caudate lobectomy for deeply/centrally located liver tumors: a new technique maximizing both oncological and surgical safety. J Hepatobiliary Pancreat Sci 2017, 24(12):E10-16.

Ozaki Y, Shindoh J, Miura Y, Nakajima H, Oki R, Uchiyama M, Masuda J, Kinowaki K, Kondoh C, Tanabe Y, Tanaka T, Haruta S, Ueno M, Kitano S, Fujii T, Udagawa H, Takano T. Serial psudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: a case report. BMC Cancer 2017; 17(1):778.

Shindoh J. Ablative Therapies for Intrahepatic Cholngiocarcinoma. Hepatobiliary Surg Nutl 2017;6(1):2-6.

2016年
Shindoh J, Makuuchi M, Matsuyama Y, Mise Y, Arita J, Sakamoto Y, Hasegawa K, Kokudo N. Complete removal of the tumor-bearing portal territory improves the survival of patients with hepatocellular carcinoma. J Hepatol 2016, 64(3):594-600.

Oba M, Hasegawa K, Shindoh J, Aoki T, Sakamoto Y, Sugawara Y, Makuuchi M, Kokudo N. Real impact of repeat surgery on post-recurrence survival sfter hepatic resection in patients with colorectal liver metastases. Surgery 2016; 159(2): 632-40.

Okura Y, Shinohara H, Shindoh J, Haruta S, Ueno M, Sakai Y, Udagawa H. A new scoring system using preoperative factors and contour mapping for predicting postoperative complications of laparascopic gastrectomy. Dig Surg 2016;33(1):74-81.

Shindoh J, Nishioka Y, Yoshioka R, Sugawara T, Sakamoto Y, Hasegawa K, Hashimoto M, Kokudo N. KRAS mutation status predicts site-specific recurrence and survival afer the resection of colorectal liver metastases irrespective of the location of the primary lesion. Ann Surg Oncol 2016;23(6):1890-6.

Ribero D, Zimmitti G, Aloia TA, Shindoh J, Forchino F, Amisano M, Passot G, Ferrero A, Vauthey JN. Preoperative cholangitis and future liver remnant volume determine the risk of liver failure in patients undergoing resection for hilar cholangiocarcinoma. J Am Coll Surg 2016; 223(1):87-97.

Shindoh J, Akamatsu N, Tanaka T, Kaneko J, Tamura S, Sakamoto Y, Hasegawa K, Sugawara Y, Makuuchi M, Kokudo T. Risk factors for acute liver allograft rejection and their influences on treatment outcomes of rescue therapy in living donor liver transplantation. Clin Transpl 2016, 30(8):880-5.

Nishitai R, Shindoh J, Ymaoka T, Akahane M, Kokudo N, Manaka D. Biliary architecture of livers exhibiting right-sided ligamentum teres: an indication for preoperative cholangiography prior to major hepatectomy. HPB 2016, 18(11): 929-935.

Tani K, Shindoh J, Akamatsu N, Arita J, Kaneko J, Sakamoto Y, Hasegawa K, Kokudo N. Venous drainage map of the liver for complex hepatobiliary surgery and liver transplantation. HPB 2016; 18(12):1031-1038.

Iwashita Y, Ohyama T, Honda G, Hibi T, Yoshida M, Miura F, Takada T, Han HS, Hwang TL, Shinya S, Suzuki K, Umezawa A, Yoon YS, Choi IS, Huang WS, Chen KH, Watanabe M, Abe Y, Misawa T, Nagakawa Y, Yoon DS, Jang JY, Yu HC, Ahn KS, Kim SC, Song IS, Kim JH, Yun SS, Choi SH, Jan YY, Sheen-Chen SM, Shan YS, Ker CG, Chan DC, Lee KT, Toyota N, Higuchi R, Nakamura Y, Mizuguchi Y, Takeda Y, Ito M, Norimizu S, Yamada S, Matsumura N, Shindoh J, Sunagawa H, Hasegawa H, Rikiyama T, Sata N, Kano N, Kitano S, Tokumura H, Yamashita Y, Watanabe G, Nakagawa K, Kimura T, Yamakawa T, Wakabayashi G, Endo I, Miyazaki M, Yamamoto M. What are the appropriate indicators of surgical difficulty during laparoscopic cholecystectomy? Results from a Japan-Korea-Taiwan multinational survey. J Hepatobiliary Pancreat Sci 2016;23(9):533-547.

Ohkura Y, Haruta S, Shindoh J, Tanaka T, Ueno M, Udagawa H. Effectiveness of postoperative intravenous acetaminophen after gastrectomy: a propensity score-matched analysis. Medicine 2016; 95(44):e5352.

2015年
Zimmitti G, Shindoh J, Mise Y, Kopetz S, Loyer EM, Andreou A, Cooper A, Kaur H, Aloia TA, Maru DM, Vauthey JN. RAS mutation predicts radiologic and pathologic response in patients treated with chemotherapy prior to resection of colorectal liver metastases. Ann Surg Oncol 2015;22(3):834-42.

Mise Y, Hasegawa K, Shindoh J, Ishizawa T, Aoki T, Sakamoto Y, Sugawara Y, Makuuchi M, Kokudo N. The Feasibility of Third or More Repeat Hepatectomy for Recurrent Hepatocellular Carcinoma. Ann Surg 2015; 262(2): 347-57.

Shindoh J, Hashimoto M, Watanabe G. Surgical approach for hepatitis C virus-related hepatocellular carcinoma. World J Hepatology 2015; 7(1):70-7.

Yamamoto S, Hasegawa K, Inoue Y, Shindoh J, Aoki T, Sakamoto Y, Sugawara Y, Makuuchi M, Kokudo N. Bile duct preserving surgery for hepatocellular carcinoma with bile duct tumor thrombus. Ann Surg 2015; 261(5): e123-5.

Nishioka Y, Shindoh J, Yoshioka R, Goni W, Abe H, Okura N, Yoshida S, Oba M, Hashimoto M, Watanabe G, Hasegawa K, Kokudo N. Radiologic morphology of colorectal liver matastases after preoperative chemotherapy predicts tumor viability and postoperative outcomes. J Gastrointest Surg, 2015; 19(9):1653-61.

Ohkura Y, Shindoh J, Haruta S, Kaji D, Ota Y, Fujii T, Hashimoto M, Watanabe G, Matsuda M. Primary adrenal lymphoma in a patient with rheumatoid arthritis possibly associated with Epstein-Barr virus reactivation due to immunosuppression. Medicine 2015; 94(31):e1270.

Omichi K, Shindoh J, Yamamoto S, Matsuyama Y, Akamatsu N, Arita J, Kaneko J, Sakamoto Y, Kiyoshi H, Kokudo N. Postoperative outcomes in patients with non-B non-C hepatocellular carcinoma: a subgroup analysis of patients with a past history of hepatitis B infection. Ann Surg Oncol 2015, 22:1034-40.

2014年
Shindoh J, Tzeng CD, Aloia TA, Curley SA, Huang SY, Mahvash A, Gupta S, Wallace MJ, Vauthey JN. Safety and Efficacy of Portal Vein Embolization Before Planned Major or Extended Hepatectomy: An Institutional Experience of 358 Patients. J Gastrointest Surg 2014;18(1):45-51.

Mise Y, Satou S, Shindoh J, Conrad C, Aoki T, Hasegawa K, Sugawara Y, Kokudo N. Three-dimensional volumetry in 107 normal livers reveals clinically relevant inter-segment variation in size. HPB (Oxford). 2014;16(5):439-47.

Shindoh J, Hasegawa K, Takemura N, Omichi K, Ishizawa T, Aoki T, Sakamoto Y, Suagawara Y, Kokudo N. Hepatitis C viral load predicts tumor recurrence after curative resection of hepatocellular carcinoma regardless of the genotype of hepatitis C virus. Hepatology Int 2014: l8(1):112-120.

Shindoh J, Sugawara Y, Nagata R, Kaneko J, Tamura S, aoki T, Sakamoto Y, Hasegawa K, Tanaka T, Kokudo N. Evaluation methods for pretransplant oncologic markers and their prognostic impacts in patient undergoing living-donor liver transplantation for hepatocellular carcinoma, Transpl Int 2014;27(4):391-8.

Oba M, Hasegawa K, Matsuyama Y, Shindoh J, Mise Y, Aoki T, Sakamoto Y, Sugawara Y, Makuuchi M, Kokudo N. Discrepancy between recurrence-free survival and overall survival in patients with resectable colorectal liver metastases: a potential surrogate endpoint for time to surgical failure. Ann Surg Oncol 2014;21(6):1817-24.

Huang SY, Aloia TA, Shindoh J, Ensor J, Shaw CM, Loyer EM, Vauthey JN, Wallace MJ. Efficacy and safety of portal vein embolization for two-stage hepatectomy in patients with colorectal liver metastasis. J Vasc Interv Radiol 2014;25(4):608-17.

Shindoh J, de Aretxabala X, Aloia TA, Zimmitti G, Javle M, Conrad C, Maru DM, Aoki T, Vigano L, Ribero D, Kokudo N, Capussotti L, Vauthey JN. Tumor location is a strong predictor of tumor progression and survival in T2 gallbladder cancer: an international multicenter study. Ann Surg 2014, 261(4):733-9.

Kokudo T, Hasegawa K, Yamamoto S, Shindoh J, Takemura N, Aoki T, Sakamoto Y, Makuuchi M, Sugawara Y, Kokudo N. Surgical treatment of hepatocellular carcinoma associated with hepatic vein tumor thrombosis. J Hepatol 2014, 61(3):583-8.

Lim C, Mise Y, Sakamoto Y, Yamamoto S, Shindoh J, Ishizawa T, Aoki T, Hasegawa K, Sugawara Y,

Makuuchi M, Kokudo N. Above 5 cm, size does not matter anymore in patients with hepatocellular carcinoma. World J Surg 2014, 74(4):721-7.

Shindoh J, Vauthey JN. Staging of biliary tract and primary liver tumors. Surg Oncol clin N Am 2014;23(2):313-22.１１

医学の進歩への貢献